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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human SRY (amino acids:1-204) expressed in E. Coli.|
|Storage buffer||PBS with 0.5% proprietary stabilizer|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:200 - 1:400|
|Immunohistochemistry (IHC)||1:200 - 1:1000|
|Western Blot (WB)||1:500 - 1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17181 targets SRY in FACS, IHC, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17181 immunogen is purified recombinant fragment of human SRY (amino acids:1-204) expressed in E. Coli.
MA5-17181 detects SRY which has a predicted molecular weight of approximately 23.9kDa.
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
essential protein for sex determination in human males; sex determining region Y protein; sex-determining region on Y; Sex-determining region Y protein; Testis-determining factor; testis-determining factor on Y
SRXX1; SRXY1; SRY; TDF; TDY