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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:4,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
STEAP3 Fusion Protein Ag10970 (1-204 aa encoded by BC042150) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.28 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MPEEMDKPL ISLHLVDSDS SLAKVPDEAP KVGILGSGDF ARSLATRLVG SGFKVVVGSR NPKRTARLFP SAAQVTFQEE AVSSPEVIFV AVFREHYSSL CSLSDQLAGK ILVDVSNPTE QEHLQHRESN AEYLASLFPT CTVVKAFNVI SAWTLQAGPR DGNRQVPICG DQPEAKRAVS EMALAMGFMP VDMGSLASAW EVEAM (1-204 aa encoded by BC042150)
The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dudlin 2; dudulin 2; Dudulin-2; hpHyde; hTSAP6; Metalloreductase STEAP3; pHyde; Protein nm1054; Six-transmembrane epithelial antigen of prostate 3; STEAP family member 3, metalloreductase; tumor suppressor pHyde; Tumor suppressor-activated pathway protein 6
Gene Aliases: 1010001D01Rik; AHMIO2; dudlin-2; dudulin-2; pHyde; STEAP3; STMP3; TSAP6
UniProt ID: (Human) Q658P3, (Mouse) Q8CI59, (Rat) Q5RKL5
Entrez Gene ID: (Human) 55240, (Mouse) 68428, (Rat) 170824
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