This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with bovine based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG's transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycledependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-strand breaks occurs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Esp1-associated protein; ESP1-associated protein 1; HPTTG; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTG; Securin; Tumor-transforming protein 1; TUTR1
Gene Aliases: AW555095; C87862; EAP1; HPTTG; PTTG; PTTG1; Pttg3; TUTR1