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|Tested species reactivity||Cat, Human, Primate, Rat|
|Host / Isotype||Rat|
|Immunogen||Synthetic substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) conjugated to KLH|
|Storage buffer||PBS, pH 7.5, with 0.2% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||1:50-1:200|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17201 detects Substance P from human, rat, feline, and monkey samples.
MA5-17201 has been successfully used in immunofluorescence, immunocytochemistry, and immunohistochemistry (frozen & paraffin) applications. Prolonged fixation in buffered formalin can destroy the epitope.
Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide gamma; neuropeptide K; NK2; NKNA; NPK; PPT; preprotachykinin; protachykinin; protachykinin-1; substance K; substance P; TAC1; TAC2; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Hs.2563; NK2; NKA; NKNA; NPK; Ppt5fl; PPTA3; RATPPTA3; TAC; TAC1; TAC2