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Invitrogen

TBX15/TBX18 Polyclonal Antibody

View all (2) TBX15/TBX18 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-103258

Applications Tested Dilution Publications

Western Blot (WB)

 1:1,000-1:3,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:200 -

Immunocytochemistry (ICC/IF)

 1:100-1:500 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

A synthesized peptide derived from human TBX15/18, corresponding to a region within the internal amino acids.

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Affinity chromatography

Storage buffer

 PBS, pH 7.4, with 50% glycerol

Contains

 0.02% sodium azide

Storage conditions

 -20°C

RRID

AB_2852620

Target Information

T-box transcription factors are a group of phylogenetically conserved genes that contain a uniquely defining DNA-binding domain, the T-box domain. These genes are believed to be involved in the regulation of development processes. In mouse embryo development, Tbx15 is expressed at the beginning of day 9.5, primarily in the craniofacial region and in the developing limbs. Twelve human T-box genes have been isolated so far. TBX 18 has been reported to be involved in numerous development processes and to act as an antiapoptotic factor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: droopy ear; MmTBx8; T-box 14; T-box protein 14; T-box protein 15; T-box protein 18; T-box transcription factor TBX14; T-box transcription factor TBX15; T-box transcription factor TBX18

Gene Aliases: 2810012F10Rik; 2810404D13Rik; CAKUT2; de; TBX14; TBX15; TBX18; Tbx8

UniProt ID: (Human) Q96SF7, (Human) O95935, (Mouse) O70306, (Mouse) Q9EPZ6

Entrez Gene ID: (Human) 6913, (Human) 9096, (Mouse) 21384, (Rat) 295315, (Rat) 315870, (Mouse) 76365

Molecular Function: Rel homology transcription factor

Function(s)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated embryonic cranial skeleton morphogenesis negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation renal system development regulation of transcription, DNA-templated transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis somitogenesis positive regulation of mesenchymal cell proliferation sinoatrial node development sensory perception of sound biological_process anterior/posterior axis specification morphogenesis of embryonic epithelium positive regulation of cell-cell adhesion cell differentiation anatomical structure formation involved in morphogenesis positive regulation of epithelial cell proliferation smooth muscle cell differentiation ureter development cochlea morphogenesis positive regulation of mesenchymal cell proliferation involved in ureter development multicellular organism development
Process(es)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription corepressor activity protein binding protein homodimerization activity protein heterodimerization activity transcription regulatory region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding DNA binding RNA polymerase II transcription factor binding molecular_function
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