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Invitrogen

TGFBR2 Polyclonal Antibody

1 Published Figure
4 References
View all (28) TGFBR2 antibodies
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Product Details

Applications
Tested Dilution
Publications
Western Blot (WB)
1:1000
View 1 publication 1 publication
Immunohistochemistry (IHC)
-
View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))
1:10-1:50
-
Immunocytochemistry (ICC)
-
View 1 publication 1 publication
Immunocytochemistry (ICC/IF)
1:10-1:50
-
Product Specifications
Species Reactivity
Human, Mouse
Published species
Human, Mouse
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2552386

Target Information

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: tbetaR-II; tgf beta receptor 2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFR-2; TGFR2; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; Transforming growth factor-beta receptor type II

Gene Aliases: 1110020H15Rik; AAT3; AU042018; DNIIR; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; RIIDN; TAAD2; TbetaR-II; TbetaRII; TBR-II; TGFbeta-RII; TGFBR2; TGFR-2

UniProt ID: (Human) P37173, (Mouse) Q62312

Entrez Gene ID: (Human) 7048, (Mouse) 21813

Molecular Function: TGF-beta receptor cytokine receptor kinase protein kinase protein kinase receptor receptor serine/threonine protein kinase receptor transferase

Function(s)
blood vessel development patterning of blood vessels vasculogenesis in utero embryonic development heart looping positive regulation of mesenchymal cell proliferation lens development in camera-type eye positive regulation of tolerance induction to self antigen positive regulation of B cell tolerance induction positive regulation of T cell tolerance induction outflow tract morphogenesis growth plate cartilage chondrocyte growth protein phosphorylation receptor-mediated endocytosis apoptotic process transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation Notch signaling pathway smoothened signaling pathway gastrulation brain development heart development embryo implantation aging response to nutrient positive regulation of cell proliferation response to mechanical stimulus response to glucose regulation of gene expression positive regulation of epithelial cell migration positive regulation of epithelial to mesenchymal transition peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation negative regulation of transforming growth factor beta receptor signaling pathway organ regeneration activation of protein kinase activity embryonic hemopoiesis wound healing regulation of cell proliferation response to drug myeloid dendritic cell differentiation positive regulation of skeletal muscle tissue regeneration response to estrogen positive regulation of angiogenesis response to steroid hormone digestive tract development positive regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis positive regulation of NK T cell differentiation palate development negative regulation of cardiac muscle cell proliferation pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis bronchus morphogenesis trachea formation mammary gland morphogenesis lung lobe morphogenesis response to cholesterol positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation lens fiber cell apoptotic process positive regulation of reactive oxygen species metabolic process growth plate cartilage development transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell proliferation organ morphogenesis phosphorylation cell differentiation lung development regulation of growth cartilage development lung morphogenesis bronchus development trachea morphogenesis
Process(es)
transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding glycosaminoglycan binding mitogen-activated protein kinase kinase kinase binding type I transforming growth factor beta receptor binding SMAD binding metal ion binding transforming growth factor beta binding nucleotide binding protein kinase activity protein serine/threonine kinase activity receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups type III transforming growth factor beta receptor binding

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