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Product Details
TA500532
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI10G3 |
Immunogen |
Full length human recombinant protein of human TMEM100 produced in HEK293T cell. |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.4 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Target Information
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane protein 100
Gene Aliases: TMEM100
UniProt ID: (Human) Q9NV29
Entrez Gene ID: (Human) 55273
angiogenesis
vasculogenesis
in utero embryonic development
epithelial to mesenchymal transition involved in endocardial cushion formation
Notch signaling pathway
BMP signaling pathway
protein kinase B signaling
positive regulation of endothelial cell differentiation
regulation of calcium-mediated signaling
regulation of sensory perception of pain
arterial endothelial cell differentiation
cellular response to BMP stimulus
positive regulation of vasculogenesis
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