Description: TNF-beta (LTX-21) is a mouse monoclonal antibody raised against native and recombinant TNF-beta of human origin.BMS105 specifically recognizes natural TNF-beta as well as recombinant TNF-beta (16 kDa and 18 kDa form).
The antibody can be used to stain TNF-beta producing cells. Immunoperoxidase or immunofluorescence techniques are applicable. BMS105 is also suitable as primary antibody in staining for FACS analysis,for for Western blot and ELISA application. BMS105FI can be used for direct staining of cells.
Applications Tested: ELISA, Flow Cytometry, Immunohistochemistry, Western Blotting.
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAMA-25N12.13; LT; LT-alpha; Lymphotoxin-alpha; TNF superfamily, member 1; TNF-beta; TNFB; TNFSF1; tumor necrosis factor beta; tumor necrosis factor ligand 1E; Tumor necrosis factor ligand superfamily member 1
Gene Aliases: LT; LTA; TNFB; TNFSF1; TNLG1E
UniProt ID: (Human) P01374
Entrez Gene ID: (Human) 4049