Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
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Protein Aliases: calcium-activated; Calcium-activated non-selective cation channel 1; hTRPM4; Long transient receptor potential channel 4; LTrpC-4; Melastatin-4; Transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4
Gene Aliases: hTRPM4; LTRPC4; PFHB1B; TRPM4; TRPM4B
UniProt ID: (Human) Q8TD43
Entrez Gene ID: (Human) 54795