Immunogen sequence: EEPLNLEGLV AHRVAGVQAR EKQPAEPPAP LRRRAASDGQ YENQSPEATS PRSPGVRSPV QCVSPELALT IALNPGGRPK EPHLHSYK
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 99%.
Tensin is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. However, tensin also contains a Src homology 2 (SH2) domain and has the ability to be phosphorylated. Tensin is phosphorylated on tyrosine, serine, and threonine residues, suggesting that it might participate in signal transduction cascades. These diverse characteristics in a single molecule indicate that tensin may be an important link between the cytoskeleton and signal transduction pathways.
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Protein Aliases: DKFZp586K0617; matrix-remodelling associated 6; Matrix-remodelling-associated protein 6; MGC88584; protein phosphatase 1, regulatory subunit 155; Tensin-1
Gene Aliases: MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; MXRA6; PPP1R155; TNS; TNS1
UniProt ID: (Human) Q9HBL0
Entrez Gene ID: (Human) 7145