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|Tested species reactivity||Human|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||An amino acid peptide derived from human U2AF65.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunofluorescence (IF)||See 1 publications below|
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Rat||Not Cited||RNA splicing capability of live neuronal dendrites.||Glanzer J,Miyashiro KY,Sul JY,Barrett L,Belt B,Haydon P,Eberwine J||Proceedings of the National Academy of Sciences of the United States of America (102:16859)||2005|
hU2AF(65); hU2AF65; splicing factor U2AF; splicing factor U2AF 65 kD subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 snRNP auxiliary factor large subunit; U2AF65