PA1-759 detects ubiquilin from hamster cells.
PA1-759 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~63 kDa protein representing ubiquilin from CHO cell extract.
PA1-759 immunizing peptide corresponds to amino acids residues 2-18 from mouse ubiquilin.
Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by an aspartyl protease (BACE). Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Associated with the presenilins are nicastrin and ubiquilin: nicastrin has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Ubiquilin is believed to promote presenilin protein accumulation. Also found in the neurofibrillary lesions associated with Alzheimer's disease is Tau, a neuronal microtubule-associated protein found predominantly on axons that functions to promote tubulin polymerization and stabilize microtubules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; DA41; Dsk2; hPLIC-1; PLIC-1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; ubiquilin 1; Ubiquilin-1; XDRP1
Gene Aliases: 1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; DA41; DSK2; I79_020705; PLIC-1; PLIC1; UBQLN1; UBQN; XDRP1