Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (90%), Rat (90%), Sheep (96%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hPLIC-1; PLIC-1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; Ubiquilin-1
Gene Aliases: 1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; DA41; DSK2; PLIC-1; PLIC1; UBQLN1; UBQN; XDRP1