This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
MA5-11447 targets CD106 in IHC (P, F) and ICC/IF applications and shows reactivity with Human samples.
The MA5-11447 immunogen is stimulated human umbilical vein endothelial cells (HUVEC).
MA5-11447 has been successfully used in immunohistochemistry analysis of VCAM1 in mouse E16.5 frozen lung sections.
CD106 (also known as vascular cell adhesion molecule-1 (VCAM-1) and INCAM-110) is a member of the Ig superfamily of adhesion molecules and is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on unstimulated endothelial cells. It is also present on follicular and interfollicular dendritic cells of lymph nodes, myoblasts, and some macrophages. CD106 serves as a ligand for leukocyte integrin alphaBeta (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in tumor metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD106; CD106 antigen; DKFZp779G2333; INCAM-100; MGC99561; V-CAM 1; Vascular cell adhesion protein 1
Gene Aliases: CD106; INCAM-100; Vcam-1; VCAM1
UniProt ID: (Human) P19320
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor