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Abnova

VCP Monoclonal Antibody (2B2)

View all (37) VCP antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

H00007415-M18

Applications Tested Dilution Publications

Western Blot (WB)

 1-5 µg/mL -

Immunocytochemistry (ICC/IF)

 10 µg/mL -

ELISA (ELISA)

 10 µg/mL -
Product Specifications

Species Reactivity

 Human

Host/Isotype

 Mouse / IgG1, kappa

Class

 Monoclonal

Type

 Antibody

Clone

 2B2

Immunogen

VCP (NP_009057.1, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 See Label

Purification

 Affinity chromatography

Storage buffer

 PBS, pH 7.4

Contains

 no preservative

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Sequence of this protein is as follows: MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY

Target Information

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; epididymis luminal protein 220; epididymis secretory protein Li 70; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog

Gene Aliases: ALS14; CMT2Y; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; p97; TERA; VCP

UniProt ID: (Human) P55072

Entrez Gene ID: (Human) 7415

Function(s)
DNA repair double-strand break repair NADH metabolic process ER to Golgi vesicle-mediated transport autophagy activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus positive regulation of mitochondrial membrane potential protein ubiquitination protein N-linked glycosylation via asparagine viral genome replication translesion synthesis ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein hexamerization ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization positive regulation of protein catabolic process ATP metabolic process protein homooligomerization aggresome assembly error-free translesion synthesis ER-associated misfolded protein catabolic process flavin adenine dinucleotide catabolic process autophagosome maturation positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity regulation of aerobic respiration positive regulation of oxidative phosphorylation positive regulation of ubiquitin-specific protease activity positive regulation of ATP biosynthetic process
Process(es)
protein binding ATP binding lipid binding ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding poly(A) RNA binding BAT3 complex binding ubiquitin-specific protease binding
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