This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. The two other subunits of ESCRT-I are vesicular protein sorting 23, also known as tumor susceptibility gene 101 (TSG101), and vesicular protein sorting 37. Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.
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Protein Aliases: Caspase-activated DNase inhibitor that interacts with ASK1; CIIA; ESCRT-I complex subunit VPS28; H-Vps28; MGC60323; vacuolar protein sorting 28 homolog; vacuolar protein sorting 28-like protein; Vacuolar protein sorting-associated protein 28 homolog; VPS28, ESCRT-I subunit; yeast class E protein Vps28p homolog
Gene Aliases: 1110014J03Rik; CIIA; D730005C08Rik; VPS28
Molecular Function: membrane traffic protein