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Product Details
MA5-42517
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
Flow Cytometry (Flow) |
1:50-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Expression System |
HEK293 cells |
Class |
Recombinant Monoclonal |
Type |
Antibody |
Clone |
JE58-28 |
Immunogen |
Recombinant protein within human WDR4 aa 262-412 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
TBS, pH 7.4, with 40% glycerol |
Contains |
0.05% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2911658 |
Product Specific Information
Positive Control: K562 cell lysates, human liver carcinoma tissue, human cervical carcinoma tissue, human ovarian tumor tissue, Daudi.
Subcellular Location: Nucleus, Chromosome.
Target Information
Required for 7-methylguanosine modification of tRNA. This protein is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD). which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes. including cell cycle progression. signal transduction. apoptosis. and gene regulation. This protein is excluded as a candidate for a form of nonsyndromic deafness (DFNB10). but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternative splicing of this gene generates at least 3 transcript variants. two of which diverge at the 3' UTR and thus encode the same protein products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hWH; Protein Wuho homolog; TRM82 tRNA methyltransferase 82 homolog; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; WD repeat-containing protein 4; WDR4
Gene Aliases: TRM82; TRMT82; WDR4
UniProt ID: (Human) P57081
Entrez Gene ID: (Human) 10785
Molecular Function:
RNA metabolism protein
RNA processing factor
nucleic acid metabolism protein
Performance Guarantee
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