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Product Details
MA5-34898
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C8
Immunogen
Synthetic peptide within Human xanthine dehydrogenase aa 1,082-1,131
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848804
Product Specific Information
Positive Control: Human liver tissue, human kidney tissue, LOVO.
Target Information
XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody
Gene Aliases: XDH; XDHA; XO; XOR
UniProt ID: (Human) P47989
Entrez Gene ID: (Human) 7498
xanthine dehydrogenase activity
xanthine oxidase activity
iron ion binding
electron carrier activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors
protein homodimerization activity
molybdopterin cofactor binding
flavin adenine dinucleotide binding
2 iron, 2 sulfur cluster binding
oxidoreductase
metabolite interconversion enzyme
negative regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
purine nucleotide catabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
lactation
xanthine catabolic process
negative regulation of gene expression
negative regulation of endothelial cell differentiation
negative regulation of protein kinase B signaling
oxidation-reduction process
positive regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of reactive oxygen species metabolic process
negative regulation of vasculogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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