MA1-21460 detects XPA in human samples.
MA1-21460 has been successfully used in ELISA, Immunofluorescence, dot blot and Western Blot procedures. Positive controls of LS174T, MCF-7 cells or human tonsil suggested. Works on pure and partially purified protein but not on crude cell extract.
The MA1-21460 immunogen is recombinant human XPA (Xeroderma Pigmentosum group A) protein.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting(unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
Gene Aliases: XP1; XPA; XPAC
UniProt ID: (Human) P23025
Entrez Gene ID: (Human) 7507