Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSSEVSARRD AKKLVRSPSG LRMVPEHRAF GSPFGLEEPQ WVPDKECRRC MQCDAKFDFL TRKHHCRRCG KCFCDRCCSQ KVPLRRMCFV DPVRQCAECA LVSLKEAEFY DKQLKVLLSG ATFLVTFGNS EKPETMTCRL SNNQRYLFLD GDSHYEIEIV HISTVQILTE GFPPGGGNAR ATGMFLQYTV PGTEGVTQLK LTVVEDVTVG RRQAVAWLVA MHKAAKLLYE SRDQ
ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FYVE domain containing 21; HCV p7-transactivated protein 1; ZF21; Zinc finger FYVE domain-containing protein 21; zinc finger, FYVE domain containing 21
Gene Aliases: HCVP7TP1; ZF21; ZFYVE21
UniProt ID: (Human) Q9BQ24
Entrez Gene ID: (Human) 79038
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