This antibody is predicted to react with bovine, mouse, rat and rabbit based on sequence homology.
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARR1; ARRB1; arrestin 2; Arrestin beta-1; arrestin, beta 1; Beta-arrestin-1; Non-visual arrestin-2
Gene Aliases: ARB1; ARR1; ARRB1
UniProt ID: (Human) P49407
Entrez Gene ID: (Human) 408
Molecular Function: enzyme modulator