This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA1-078 detects eIF2B3 in human, non-human primate and rat samples and has been successfully used in Western blot, ICC/IF, IHC (P) and immunoprecipitation applications.
The immunogen for MA1-078 is full length human eIF2B3 produced in HEK293T cells.
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EIF-2B; eIF-2B GDP-GTP exchange factor subunit gamma; EIF2Bgamma; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); eukaryotic translation initiation factor 2B, subunit 3 gamma; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; Translation initiation factor eIF-2B subunit gamma
Gene Aliases: EIF-2B; EIF2B3; Eif2bg; EIF2Bgamma
Molecular Function: G-protein modulator RNA binding protein enzyme modulator guanyl-nucleotide exchange factor nucleic acid binding nucleotidyltransferase transferase translation factor translation initiation factor