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Non-HLA Antibodies: A New Perspective on Allograft Injury & Rejection | Annette Jackson
Dr. Jackson, provides a detailed introduction to non-HLA antibodies, discusses their potential impact to transplantation, and reviews new developments in their characterization.
ABO Blood Subgrouping and Implications in Transplantation | William Lane
Understand ABO genotyping, how it enables ABO minor incompatible (ABOi) transplants and the technologies and resources that are available to help labs perform ABOi transplants.
Assessing HLA Antibodies: Can we understand the strength? | Nicole Valenzuela
Learn about HLA antibody testing, interpretation of HLA antibody profiles, and the utility of serum dilution and C1qScreen in this discussion led by Dr. Nicole Valenzuela.
The Usefulness of Epitope Analysis When Interpreting HLA Antibody Test Results | Robert Liwski
Dr. Robert Liwski provides an overview of the HLAMatchmaker approach and explores the key role of epitope analysis in HLA antibody testing through literature review and case studies.
The Evolution of Risk Assessment in Solid Organ Transplantation | Kelley Hitchman
Dr. Kelley Hitchman gives an overview of advancements in crossmatch testing, examines the practicality and advantages of virtual crossmatching, and reviews requirements that impact labs.
New Frontiers in Expanded Single Antigen Testing | Jakob Nilsson
Dr. Jakob Nilsson gives a preliminary summary of his experience using LABScreen Single Antigen ExPlex, and assesses the test’s ability to predict possible binding epitopes through HLAMatchmaker.
AllType Next Generation Sequencing – Easy Integration and Future Innovation | Elizabeth Wroe
Elizabeth Wroe showcased the NHSBT’s rigorous selection criteria and provided an in-depth look of the lab’s integration of the AllType NGS assay into routine laboratory practice.
Allele-specific DSA: Lessons from SAB and NGS | Gerald P. Morris
Dr. Morris explores the limitations of solid-organ HLA genotyping methods that may preclude DSA identification and discussed various approaches for monitoring allele-specific anti-HLA antibodies. 
The Kinetics of Anti-HLA Antibody in Simultaneous Liver-Kidney Transplantation | Matthew Cusick
Dr. Matthew Cusick will provide an assessment of the impact that DSAs may have on simultaneous liver-kidney transplants and discuss how the liver may play a key role in antibody clearance.
UNOS Kidney Allocation: The Evolving Landscape | Cathi Murphey Half
A lab monitored kidney transplant statistics after the March 2021 point-based kidney allocation policy was implemented and used the UNOS kidney simulation model (KPSAM) to assess its predictive value.
Filling in the gaps: A Single-Center Experience with ExPlex | Kelley Hitchman
A laboratory was able to detect HLA reactivity that would have previously gone undetected in Hispanics without having to perform additional tests, saving time and resources.
AllType™ FASTplex™ v2: Our HLA Laboratory Experience | Ahmed Mostafa
Discover how NGS and antibody detection can be combined for broader applications, including virtual crossmatching, to support changes to the kidney allocation system.
Adapting Laboratory Diagnostics to a Changing Landscape | ASHI 2021
Discover how NGS and antibody detection can be combined for broader applications, including virtual crossmatching, to support changes to the kidney allocation system.
Review of AllType FASTplex™ NGS assay & TypeStream Visual NGS Analysis Software v2.1 | Peter Brescia
Login Required | In-depth review of our new AllType™ FASTplex™ NGS assay v2 protocol as well as our updated version of TypeStream™ Visual NGS Analysis Software v2.1
LATAM Virtual Workshop
This session includes an introduction to the HLA Fusion functionality, and a review of challenging case studies of LABType, LABScreen, LinkSeq, and AllType.
LATAM Taller Virtual - Español
Esta sesión incluye una introducción a la funcionalidad HLA Fusion, una revisión de los estudios de casos desafiantes de LABType, LABScreen, LinkSeq, y AllType.
Are Dilutions the Solution? Identifying the True Extent of Patient Sensitization
In this presentation, Drs. Mark Stegall and Anat Tambur discuss how serial dilutions of the LABScreen™ Single Antigen assay aid in the assessment of alloantibody levels.
Directory: Advanced Virtual Workshop Series
Learn how to process samples using LABType, LABScreen, AllType, and LinkSeq products as well as how to create custom analysis reports using HLA Fusion, TypeStream, and SureTyper software.
Basic Immunology and the HLA Complex | Bedrich Prokupek
In the context of transplant medicine, this program will review immunology basics and the structure and function of the HLA complex for both Class I and Class II. 
The Role of Race in Transplant and Transfusion: a Roundtable Discussion | Patient Stories
HLA experts discuss the need for a more diverse donor pool and the impact that the COVID-19 pandemic is having on minority donor recruitment in transplant and transfusion.
Vein to Vein: RBC Alloimmunization, Genotyping & Inventory Management | Drs. Stella Chou and Monica Kalvelage
Hear from industry leaders as they discuss transfusion medicine, challenges of finding donors, managing blood bank inventory, as well as the benefits of preventing alloimmunization.
Virtual crossmatch strategy to facilitate kidney transplantation for highly sensitized candidates | Rajalingam Raja
In this talk, Dr. Raja delves into key considerations for highly sensitized candidates.
Increasing Access to Transplantation for the Highly Sensitized Patient: Combining the Latest Innovations in HLA Typing, Antibody Detection and Data Analysis | Taba Kheradmand and Robert Liwski
We explore how the evolution of more efficient NGS workflows and advanced Single Antigen assays with extended allele coverage can improve analysis with Epitope Matching and Virtual Crossmatching.
The Quest to Decipher HLA Immunogenicity: Telling Friend from Foe | Anat Tambur
Dr. Tambur explores a new way to interrogate molecular mismatch load and discusses important concepts in immunogenicity.
Video: APAC Virtual Workshop
This session features an overview of SureTyper, TypeStream Visual, HLA Fusion, HLA MatchMaker, and a discussion on virtual crossmatch testing with Donna Phelan.
Video: TypeStream™ Visual 2.0.1
Learn data reporting and exporting, comparing results, plus new features like NGS configurations for analysis parameters, customizable health metrics.
Video: AllType™ & AllType FASTplex
Our instructors provide an introduction to our AllType and AllType FASTplex products plus an examination of challenging NGS case studies.
Video: LABType™ and HLA Fusion™ 4.6
A comprehensive review of the LABType analysis module in HLA Fusion with emphasis placed on new features and functionality implemented in versions 4.0 and above.
Video: LABType™ and Specific Case Studies
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: HLA MatchMaker | LABScreen™ Single Antigen Beads in HLA Fusion™ 4.6
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: HLA MatchMaker | LABScreen™ Single Antigen Beads in HLA Fusion™ 4.6 (Case Studies)
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: LinkSēq™ for both HLA and Transfusion Products
In this session, we review key software functionality in both the latest SureTyper and SureTyper Blood analysis software applications.
Video: LinkSēq™ for both HLA and Transfusion Products (Case Studies)
A high-level product overview of rt PCR products for HLA and Blood Transfusion, with case studies designed to highlight challenging sample analysis and critical points in the LinkSeq assay.
Video: New Antibody Advances
Discussion on developments and quality improvements of our LABScreen antibody products and a discussion on the future of antibody testing.
Video: Potential of Imlifidase
Learn how Imlifidase specifically targets IgG and inhibits pathogenic IgG-mediated immune responses in transplant patients and patients with autoimmune disease or cancer.
Video: Advancements in AllType FASTPlex
Improvements include an optimized primer mix for 11 HLA loci, more robust PCR amplification, greater on-target accuracy, an improved DRB primer design, and better locus balance.
Video: An Introduction to and the Evolution of the UK Living Kidney Sharing Scheme
Learn how Imlifidase specifically targets IgG and inhibits pathogenic IgG-mediated immune responses in transplant patients and patients with autoimmune disease or cancer.
Video: HLA Typing by Next-Generation Sequencing (NGS) Using the AllType Fastplex Kit and the Relevance of Anti-HLA Antibody Monitoring After Kidney Transplantation
Dr. Andreani shares his laboratory’s evaluation of One Lambda™ AllType™ FASTPlex™ NGS showing 100% concordance on 240 and demonstrates how his lab determines a patient’s eplet load using HLAMatchmaker
Video: Non-HLA Antibodies: Preliminary Experience
A case study of nine patients that had high levels of REG3A, LMNB, PRKCH, GAPDH, HNRNPK, VM, and IFNG autoantibodies; correlated with humoral rejection in kidney and heart transplant recipients.
European Virtual Workshop
Learn key software functionality for HLA Fusion 4.6 and TypeStream Visual 2.1. Includes challenging AllType, LABType, LABScreen, and LinkSēq case studies, and an overview of HLA MatchMaker.
Fishing in a Pond with More Fish: Refining the HLA Antibody Assignment Using the LABScreen Single Antigen ExPlex Bead Panel
In this webinar, we explore how some “pan-reactive” antibodies expressing less common HLA alleles can be dismissed as potential false positives.
AllType FASTplex NGS: Frag, Tag, Pool, and GO! | Dawn Thomas
Thinking of updating your NGS protocol to the new AllType FASTplex? See how Allogen Laboratories gained efficiencies by making the switch and the validation data.
A Roadmap for Novel HLA Alleles from Discovery to Submission | Ahmed Mostafa
What constitutes a novel allele? Dr. Ahmed Mostafa defines what constitutes a novel allele and will demonstrate how to use TSV to identify one and submit the novel allele to the IPD-IMGT/HLA database.
Treating Sera with Non-Specific Interference in SAB Assays | Luis Hidalgo
In our User Group Meeting, Dr. Luis Hidalgo discussed a variety of cases where our PreSorb reagent impacted unexpected reaction patterns in single antigen bead tests.
Selecting and Implementing Next-Generation DNA Sequencing HLA Genotyping | Gerald Morris
NGS is becoming cheaper and easier for resolving ambiguities in HLA alleles. In this talk from our User Group Meeting 2022, Dr. Gerald Morris discussed how smaller labs could introduce NGS genotyping.
Extended HLA Antibody Profiling: How Might it Help in Immunological Risk of Assessment in the Era of Histocompatibility Testing | Siva Kanangat
At our 2022 User Group Meeting, Dr. Siva Kanangat shares a presentation on extended HLA antibody profiling as a tool for immunological risk assessment in histocompatibility testing.
Understanding Epitopes | Dave Lowe
This 2022 User Group Meeting talk highlights how tools to identify epitope-specific patterns are now available as sophisticated software suites for histocompatibility testing in transplantation.
Site-Directed Mutagenesis of HLA Molecules: A New Approach for HLA Eplet Verification
Dr. Suzanne Bezstarosti shared an approach to epitope differentiation with site-directed mutagenesis and discusses how the exact binding residues of HLA-specific monoclonal antibodies were evaluated.
A Proposed Update for the Definition of HLA Serologic Specificities Considering Structural Features that Determine Serologic Epitopes
During this User Group Meeting session, the speakers proposed an updated HLA nomenclature system that would enable any HLA allele to be delineated into one of a group of designated serotypes.
Discovering the Power of HistoTrac Software for Your HLA Laboratory | Yanping Huang
Listen to Dr. Yanping Huang detail the journey of her HLA lab implementing HistoTrac software. Discover the capabilities of the software’s basic functions, custom modules, and new management system.
Introducing the HLA Assay as a Companion Diagnostic in Immunotherapy Development
Watch this webinar to see Dr. Sean Carey and Lee-Anne Zinetti highlight the critical role of HLA in cancer immunotherapy and overview the development of a companion diagnostic for precision medicine.
Detection of dd-cfDNA from Both Grafts in the Setting of a Second Kidney Transplantation by a New NGS-Based Assay
Watch this on-demand webinar to see Dr. Jakob Nilsson discuss a new NGS-based assay used to detect donor-derived cell-free DNA from grafts when monitoring patients after a kidney transplantation.
2023 Virtual Software Training
This series of six virtual workshops trains users on how to use LABType assays, TypeStream Visual software, LABScreen assays, AllType NGS assays, AllType FASTplex assays, and HLA Matchmaker software.
PubSummary | Analysis of RNA Transcripts by the Molecular Microscope Diagnostic System Can Direct Management after Indication Kidney Transplant Biopsy
These two cases describe how MMDx was used to aid the management of two patients with Banff diagnoses of “borderline” and “Banff 1a TCMR.”
Innovations in Rejection Surveillance after Heart Transplantation | Jon Kobashigawa
For post-transplant management in heart patients, the endomyocardial biopsy is considered the gold standard to detect acute rejection.
PubSummary | Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection
The study describes the molecular landscape of antibody mediated rejection.
PubSummary | Revisiting the changes in the Banff Classification for antibody‐mediated rejection after kidney transplantation
In the search for potential treatments and personalized prognostication, a clear definition of antibody mediated rejection (ABMR) is an indispensable prerequisite.
Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging
We previously characterized the molecular changes in acute kidney injury (AKI) and chronic kidney disease (CKD) in kidney transplant biopsies, but parenchymal changes selective for specific types ...
Specimen Collection Procedure for the Molecular Microscope Diagnostics System (MMDx)
Thinking of ordering an MMDx specimen collection kit? See what's in the kit and how to collect the specimen and ship it to the lab for assessment.
Introduction to the Molecular Microscope Diagnostic System (MMDx)
What is MMDx and how does it work? Dr. Christopher Lawrence gives a brief overview of the biopsy service.
The Molecular Microscope Diagnostic System: Precision and Accuracy in Transplant Diagnostics | Philip Halloran
Dr. Phil Halloran discusses the unmet need for precision and accuracy in pathological biopsy assessment and reviews the applications of the actionable data generated in MMDx reports.
Case Study | A Challenging Diagnosis in Kidney Transplantation: MMDx Kidney
In a case where a highly sensitized patient received abnormal biopsy results after transplantation, gene expression profiling provided the treating clinician with confirmatory results for diagnosis.
Molecular phenotypes of liver transplant injury: the INTERLIVER study
ATC2020 Presentation by KS Madill-Thomsen, PF Halloran, and the INTERLIVER Study Group
MMDx Kidney Report Sample
What information will the MMDx-Kidney Assessment Report provide? This sample will show you how to interpret the report.
Cross-organ comparisons: Temporal Gene Expression Changes In Kidney, Heart, Liver, and Lung Transplant Biopsies
ATC2020 Presentation by PF Halloran, J Reeve, and the INTERLIVER, INTERLUNG, INTERCOMEX, INTERHEART Study Groups
PubSummary | Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies
This study demonstrates the reproducibility of MMDx and the lack of significant disagreement between MMDx sign outs.
Clinical Applications for MMDx®: Gene Expression Profiling in Transplant Biopsies | Georg Böhmig
Molecular assessment was applied to diagnose allograft dysfunction and to determine if rejection was due to ABMR, TCMR, or a combination of both.
PubSummary | A 2020 Banff Antibody Mediated Injury Working Group examination of international practices for diagnosing antibody mediated rejection in kidney transplantation
Biopsy data is accompanied by DSA data in +/- 30% of cases, suggesting urgent action to improve the accessibility of DSA information is needed.
PubSummary | Long Term Survival after Kidney Transplantation
Long-term kidney transplant graft and patient survival have improved with time due to a superior understanding of pre-transplant immunological risk.
MMDx Heart & Kidney Brochure
MMDx Heart Brochure
MMDx Kidney Brochure
MMDx Kidney, Heart & Lung Brochure
MMDx Heart Patient FAQs
MMDx Kidney Patient FAQ
Using Molecular Diagnostics for Kidney Transplants: Getting There! | Gaurav Gupta
Explore how molecular diagnostics can be used in clinical practice, including how the test can complement traditional histology as well as how the results can be incorporated into patient management.
US payer budget impact of a microarray assay with machine learning to evaluate kidney transplant rejection in for-cause biopsies
Dr. Chris Lawrence explores how a US payer budget model demonstrates that MMDx® Kidney is a cost-effective intervention despite the cost of the assay and the higher treatment costs associated with identifying more rejection.
Novel Technology Has Made It Possible To Diagnose A New Clinical Phenotype Of Rejection Called Early Antibody Mediated Rejection, With Significant Therapeutic Implications For Renal Allograft Survival
Discover how MMDx Kidney can diagnose antibody-mediated rejection (AMBR) when histopathology is discordant with the clinical scenario. While there is still no FDA-approved treatment for ABMR. It is suggested that identifying early ABMR could lead to intervention and the prevention of graft loss due to chronic active ABMR.
How Emerging Technologies Are Filling The Gaps And Positively Impacting Post-Transplant Care
Join Drs. Rajeev Sharma and Jamil Azzi to learn how new molecular solutions can provide clinical utility and enhance the patient experience. Valen Keefer provides a unique perspective to consider.
The Value of MMDx in Diagnostic Uncertainty for Patients with Heart Transplantation: A Case-Based Presentation
In this presentation, Dr. Guha explores heart transplant patient cases in which clinical presentation and pathological diagnosis on biopsy are discrepant and gene expression profiling was used.
PubSummary | The Molecular Microscope Diagnostic System (MMDx) Interpretation of Solid Organ Allograft Biopsies: Restoring the Perspective
MMDx Kidney helps refine the histopathologist’s findings that is not possible through light microscopy and support ABMR diagnosis where C4d or DSA results are either unavailable or negative.
Molecular Assessment of Rejection in Pediatric Heart Transplantation: A Complement to Histopathology
Watch this webinar to hear Drs. Magnetta and Arva discuss MMDx Heart, a tool that combines histopathology with molecular techniques to provide a more accurate diagnosis for organ transplant rejection.