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POU2F3, also known as Epoc-1, is a member of a family of POU domain family of transcription factors. POU2F3 is expressed primarily in the epidermis and plays a critical role in keratinocyte proliferation and differentiation. It is a crucial transcription factor that is required for the development of sweet, umami, and bitter, but not sour taste receptor cells. POU2F3 is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer.
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