CD16a, CD16a antigen, CD16b, Fc fragment of IgG low affinity IIIa receptor, Fc fragment of IgG, low affinity III, receptor for (CD16), low affinity IIIa, receptor (CD16a), low affinity IIIb, receptor (CD16b), Fc gamma receptor III-A, Fc gamma receptor IIIa, Fc gamma receptor IIIb, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIII-beta, Fc-gamma RIIIa, fc-gamma RIIIb, FcgammaRIIIA, FcR-10, IgG Fc receptor III-1, IgG Fc receptor III-2, immunoglobulin G Fc receptor III, Low affinity immunoglobulin gamma Fc region receptor III-A, Low affinity immunoglobulin gamma Fc region receptor III-B, neutrophil-specific antigen NA
Human FCGR3A/CD16A quantitates human FCGR3A/CD16A in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human FCGR3A/CD16A.
CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms – FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
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