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Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
25 kDa caspase-9 dominant negative protein; AI115399; Apaf3; APAF-3; apoptotic protease activating factor 3; apoptotic protease Mch-6; Apoptotic protease-activating factor 3; AW493809; CASP9; CASP-9; Casp9_v1; Casp-9-CTD; caspase 9; caspase 9, apoptosis-related cysteine peptidase; caspase-9; caspase-9 dominant negative form; Caspase-9 subunit p10; Caspase-9 subunit p35; caspase-9-carboxyl-terminal divergent; ICE-LAP6; ICE-like apoptotic protease 6; Mch6; PPP1R56; protein phosphatase 1, regulatory subunit 56
150 µL
150 µL
100 µL
100 µL
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