MA1065A488 detects clathrin heavy chain in non-human primate, bovine, human, rat and mouse tissues as well as hamster (CHO) cells.
The MA1065A488 immunogen is purified human brain clathrin heavy chain. Electron microscopy and proteolysis mapping demonstrate that MA1065A488 binding occurs towards the central hub of the triskelion, N-terminal to the light chain binding regions.
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3110065L21Rik; BOS_18343; CHC; CHC17; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; clathrin, heavy chain (Hc); clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; CLH-17; CLTCL2; Hc; R74732
Gene Aliases: 3110065L21Rik; BOS_18343; CHC; CHC17; CLH-17; CLH17; CLTC; CLTCL2; Hc; KIAA0034; R74732