Reactivity has been confirmed with human Caco-2 and canine MDCK cell lysates, mouse kidney and intestinal lysates, frozen mouse intestine (jejunum) tissue, and rat kidney homogenates.
|This antibody is specific for the C-terminal region of the claudin-1 protein. On western blots, it identifies the target band at ~22 kDa.
Claudin-1 is a member of the transmembrane protein superfamily of claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin. The claudin (CLDN) superfamily consists of at least 18 homologous proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport, complexed with two other integral transmembrane proteins, occludin and junctional adhesion molecule. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins interact directly with tight junction-specific, membrane-associated guanylate kinase homologues, ZO-1, ZO-2, and ZO-3, and indirectly with AF-6 and the myosin-binding molecule cingulin. These protein-protein interactions promote scaffolding of the tight junction transmembrane proteins and provide a link to the actin cytoskeleton for transducing regulatory signals to and from tight junctions. Human claudin-1, like other claudin proteins, participates in cell-cell adhesion and regulates paracellular and transcellular transport of solutes across human epithelia and endothelia. Recently, a claudin-1 cDNA has been isolated from human mammary epithelial cells (HMECs). As claudin-1 expression is low or undetectable in a number of breast tumors and breast cancer cell lines, it may be implicated as a possible tumor-suppressor gene.
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Protein Aliases: Claudin-1; CLD1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1
Gene Aliases: AI596271; CLD1; CLDN1; ILVASC; SEMP1; UNQ481/PRO944