Understanding Methylation in Colon Cancer Application Note

Discover the potential of methylated DNA analysis in colon cancer research

Globally, colon cancer is one of the most common types of cancer¹. The analysis of methylated DNA has enormous potential for understanding regulation of gene expression, epigenetic inheritance, and biomarker discovery and deployment.

 

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      Download this application note to learn:

      • Efficient DNA extraction and MSI analysis—utilize the KingFisher Apex Purification System and MagMAX FFPE DNA/RNA Ultra Kit to seamlessly extract DNA from formalin-fixed, paraffin-embedded (FFPE) colon tumor samples, enabling precise microsatellite instability (MSI) analysis with the TrueMark MSI Assay
      • Detailed methylation insight—gain comprehensive insights into the methylation state at specific bases within an amplicon through Sanger sequencing of bisulfite-converted FFPE DNA, providing critical data for your research
      • Quantitative methylation analysis—accurately quantify the fraction of methylation at a particular base using advanced techniques such as Sanger sequencing or digital PCR, ensuring high-resolution results for your studies
      • Streamlined workflow for colon cancer research—benefit from a complete and automated workflow for translational research of methylated DNA in colon cancer, encompassing DNA recovery from FFPE samples, MSI analysis, Sanger sequencing, and digital PCR, all designed to enhance efficiency and reliability in your research processes
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      1. Bray F, et al. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. doi.org/10.3322/caac.21492

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