Fisherbrand SickleScreen products use a modified Nalbandian procedure that provides fast and accurate results for screening and detecting hereditary sickle cell disease and sickle cell trait. When sickle cell patients are in crisis, their Hb S becomes sickle or cresent shaped and can no longer carry oxygen. The abnormal cells often break apart and can cause damage to the spleen, kidneys, bone, eyes, lungs and central nervous system.
The procedure is based on the differential solubility of Hemoglobin S (Hb S) and Hemoglobin A (Hb A) in concentrated phosphate solution.
The 120-test kit contains phosphate buffer (4 x 125mL) and four sodium hydrosulfite vials.
The 30-test kit contains a bottle of phosphate buffer (125mL) with a dispensing cap and 30 pre-filled reaction vials
Positive and negative controls are for Hb A and Hb S.
The control kit (22-251-051) must be ordered separately.