An improved formulation used for RNA sample denaturation in any glyoxal gel protocol. The volume ratio of solution to sample is lower than in published protocols, so sample precipitation prior to gel loading is usually not required. Ethidium bromide is premixed into the solution. Supplied in six tubes containing 1 mL each. All Ambion® Gel Loading Solutions are rigorously tested for non-specific endonuclease activity, exonuclease activity, RNase activity, and for functionality. These are the same solutions we use in-house and in our kits.