Thermo Scientific™

Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

 Related applications:
Industrial Mass Spectrometry
Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.

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Superior Quantitation

  • Advanced quadrupole technology (AQT) improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices
  • Sophisticated data-independent acquisition (DIA) and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence
  • An advanced active beam guide (AABG) reduces noise and extends maintenance intervals

Enhanced Analysis of Intact Proteins

  • Optional intact protein mode provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes
  • Optional enhanced resolution ensures maximum ID confidence in top-down proteomics and lipidomics

High-Confidence Results

  • HR/AM and full-scan capabilities capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples
  • Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices
  • Better than 1ppm mass accuracy in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification
  • Fast scanning at 12Hz and spectral multiplexing suited to UHPLC applications
  • Rapid polarity switching maximizes information obtained
  • AIF and multiple dissociation techniques — in-source CID and HCD — aid in compound identification
  • Mass range to 6,000 m/z enhances detection of singly charged small molecules and biomolecules
  • More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan
For Research Use Only. Not for use in diagnostic procedures.

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Manuals & protocols