CD22 Ab-4, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Obtain accurate and reproducible results in immunohistochemistry experiments with Thermo Scientific™ CD22 Ab-4, Mouse Monoclonal Antibody, one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.

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Description

CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types.In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells. CD22 is found highly expressed in follicular mantle and marginal zone B-cells, while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

Host Species: Mouse

Clone: FPC1

Isotype: IgG1

Species Reactivity: Human. Others not tested.

Epitope: Extracellular

Immunogen: Recombinant protein encoding the external domain of human CD22

Molecular Weight: 130-140kDa

Positive Control: Tonsil

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin only)

General References:

1. Tuscano JM et al. Eur J Immunol 1996, 26:1246-1252.

2. Cyster JG and Goodnow CC. Immunity 1997,6:509-517.

3. Schlossman SF et al. eds. Leukocyte Typing V, p523-503, Oxford University Press, Oxford, 1989.

4. Sato S et al. Semin Immunol 1998, 10:287-297

5. Tedder TF et al. Annu Rev Immunol 15:481-504.

6. Knapp, W et al. eds Leukocyte Typing IV, p190-192, Oxford University Press, Oxford, 1989



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