CD37 Ab-1, Mouse Monoclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Ensure accurate, reproducible results in immunohistochemistry, immunofluorescence and flow cytometry experiments with Thermo Scientific™ CD37 Ab-1, Mouse Monoclonal Antibody.

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CD37, a tetraspan transmembrane protein, is strongly expressed on normal and neoplastic mature (sIg+) B lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD37 is absent from platelets and erythrocytes. It associates with other tetraspan transmembrane proteins and MHC class II molecules to form a large complexes at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin lymphoma (B-NHL).

Host Species: Mouse

Clone: IPO-24

Isotype: IgG2b/κ

Species Reactivity: Human. Others not tested.

Epitope: Not determined

Immunogen: Spleen cells of a patient with hairy cell leukemia

Molecular Weight: 33-55 kDa

Positive Control: Raji cells, Tonsil or lymph node

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Acetone-fixed frozen only)
  • Immunofluorescence
  • Flow Cytometry


USA: RUO; Int'l: RUO

General References:

1. Maecker HT et al. FASEB J 1997,11(6):428-442

2. Schlossman SF et al. eds. Leukocyte Typing V, p556-559, Oxford University Press, Oxford, 1995.

3. Sidorenko SP et al. Neoplasma 199239(1):3-9.

4. Sidorenko SP et al. Gematol Transfuziol 1990, 35(4):19-22

5. Angelisova P et al. Immunogenetics 199439(4):249-256.


Manuals & protocols