Host Species: Mouse
Species Reactivity: Human, Dog and Cat. Weakly cross-reacts with Mouse. Others not known.
Epitope: aa 1-433
Immunogen: Recombinant tyrosinase protein
Molecular Weight: 70-80kDa
Positive Control: Melanoma cell lines and Melanoma
Cellular Localization: Cytoplasmic Ab-1 shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Staining of melanomas with Ab-1 showed tyrosinase in melanotic as well as amelanotic variants. Ab-1 is a useful marker for melanocytes and melanomas. Occasionally a minor band at 55kDa is also detected in Western Blotting
1. Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129.