Obtain accurate, reproducible results with Thermo Scientific™ α-1-Antitrypsin Ab-1, Rabbit Polyclonal Antibody. This antibody detects alpha-1-antitrypsin (alpha-1-AT), which exists in a number of genetic variants of which MM variant is the most common.
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
Host Species: Rabbit
Species Reactivity: Human, Baboon, Monkey, Horse and Mink. Does not react with cow, kangaroo, pig, goat, sheep, cat, dog, guinea pig, mouse and chicken. Others not known.
Immunogen: Purified human serum α-1-AT
Positive Control: Tonsil
Cellular Localization: Cytoplasmic
USA: RUO; Int'l: RUO<
1. Takahashi H et al. Analytical Cellular Pathology, 1995 Sep, 9(2):135-50.
2. Filie AC et al. Modern Pathology, 1996 Sep, 9(9):888-92.