Your search for "dab2" returned 1,198 TaqMan® SNP Genotyping Assays
DAB2, clathrin adaptor protein
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
5730435J12RIK, AA960054, AI957090, D15WSU122E, D630005B22RIK, DAB2, DOC-2, DOC2, P96
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