Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
After receipt, this product should be kept at -20ºC while lyophilized and at -70°C after reconstitution in sterile distilled water for retention of full activity. After reconstitution, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. After thawing, this product is stable for at least four weeks at 4ºC. Further dilute only in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon b; Interferon beta; interferon, beta 1; RP11-113D19.1
Gene Aliases: Ifb; IFN-beta; IFNB; Ifnb1
UniProt ID: (Rat) P70499, (Mouse) P01575
Entrez Gene ID: (Rat) 24481, (Mouse) 15977
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support