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Pioneers of Omics is a new, ongoing event series designed to celebrate the important contributions of young, early career researchers in the exciting fields of multi-omics. Each session will take a particular field of omics research and showcase some of the exciting research being undertaken from around the world.
Topics include viral proteomics and how this research aids in vaccine development, cancer proteomics, single cell proteomics, native mass spectrometry for structural biology, multiplex proteomics, artificial intelligence, metabolomics and many more.
On-demand: Biomarker discovery and validation in biological fluids
Advances in sample handling and preparation combined with advanced technology and intelligent software systems to change the way biomarker discovery is being performed. Presenters: R. Bruderer, C. Jacquemin, I. Roberts, S.D. Bhosdale
On-demand: Metabolomics approaches for systems biology
Valuable insights into systems biology can be gained by developing a better understanding of the metabolomic an lipidomic pathways to complement the proteomics analysis.
Presenters: Univ. Prof. Dr. G. Koellensperger, E. Rampler, C. Coman, M. Wright Muela, T. Damiani
On-demand: A new nano UHPLC for omics and biopharma
Showcasing the new Thermo Scientific Vanquish Neo UHPLC system, followed by a discussion on the first impressions of the system. Presenters: N. Berner, A. Boychenko
On-demand: Das neue Nano-UHPLC System für Omics und Biopharma
Vorstellung des neuen Vanquish Neo UHPLC Systems und Diskussion der ersten Eindrücke und Erfahrungen mit diesem Gerät. Session in German
Presenters: K. Mechtler, M. Samonig
On-demand: Interactomics/Spatial omics
An understanding of the heterogeneity of protein interactions within a cell is vital to understanding the biology. Presenters: T. Alexandrov, M. Matzinger, A. Chernobrovkin, A. Ori, E. Villanueva
On-demand: Cancer research - towards personalized medicine
The potential to provide precise treatments through the focus of personalized medicine offers hope for the future in the treatment of cancers. Presenters: T. Geiger, N. Rattray, J. Sampaio
On-demand: Native MS for intact protein analysis
The challenge of studying intact proteins and protein complexes in their biological state is one that has been met in recent years by the development of native mass spectrometry. Presenters: O. Hale, T. El-Baba, C. Lutomiski
On-demand: Artificial intelligence in proteomics
Find out more about the enhancement enabling more efficient data acquisition schemes for increased sample throughput and instrument utilization. Presenters: Prof. Dr. M. Wilhelm, Dr. M. Fejno, K. Mechtler
Select from 10 webinars highlighting recent advancements in products and workflows methodologies to enable cutting-edge research in proteomics and metabolomics.
Metabolomics session topics
Proteomics session topics
Throughout 2020, we partnered with industry-leading experts and academia to share the latest in Omics research. From hosting multiple webinar series to launching our own virtual events, our extensive range of education content ranges from viral proteomics, cancer pathway proteomics as well as single-cell proteomics, native mass spectrometry, and much more.
The virtual event hosted a series of presentations from industry experts, a dedicated poster hall, and five virtual booths.
Presentation topics include:
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As part of our gold sponsorship at the 2020 HUPO Connect, we hosted a virtual seminar session that features two presentations.
COVID-19, a disease caused by a novel coronavirus SARS-CoV-2, is responsible for a global pandemic that has affected tens of millions of people worldwide. Upon infection with the virus, patients exhibit a wide variety of symptoms ranging from asymptomatic to severe organ damage and systemic inflammation which can result in death.
Identifying the underlying differences between patients and their response to infection is paramount to determining effective treatments and predicting disease outcomes. Proteomic profiling using Tandem Mass Tags (TMT) is one technology that enables precise measurement of protein abundances from different patient samples and/or treatments.
This seminar highlights recent advances in TMT reagent workflows and their use in recent applications to measure SARS-CoV-2 viral particle expression over time, changes in host cell signaling upon infection, differences in immune responses of mild COVID-19 versus severe cases, and identify potential drug targets and off-targets.
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Human coronaviruses (hCoV) are an increasing global health threat, as evident by the 2002 SARS epidemic caused by SARS-CoV-1, the 2012 MERS outbreak, and the ongoing COVID-19 pandemic caused by SARS-CoV-2. Despite high protein sequence similarity between SARS-CoV-1 and -2, each strain displays distinctive virulence. A better understanding of the basic molecular mechanisms mediating changes in pathogenicity of different hCoV strains is needed to develop antiviral therapeutics.
Here, we profile the virus-host protein-protein interactions of several hCoV non-structural proteins (nsps) that are critical for virus replication. We use tandem mass tag (TMT)-multiplexed quantitative proteomics to sensitively compare and contrast the interactome of nsp2 and nsp4 from three betacoronavirus strains: SARS-CoV-1, SARS-CoV-2, as well as OC43 – a less pathogenic endemic strain associated with the common cold. This approach enabled us to identify conserved host cell binding partners that may be critical for infection. For example, we identified common nsp2 and nsp4 interactors involved in endoplasmic reticulum (ER) calcium signaling and mitochondrial biogenesis, suggesting a new functional role for these proteins in modulating host processes at ER-mitochondria contact sites. At the same time, we identified interactors unique to each strain, such as an E3 ubiquitin ligase complex for SARS-CoV-1 nsp4. Using the enhanced multiplexing capacity of TMTpro, we have now extended our comparative interactomics workflow to other hCoV nsps and additional virus strains.
Our results can reveal unknown roles these hCoV proteins play in the infection cycle, as well as host factors that may mediate the divergent pathogenicity between endemic and epidemic strains. Importantly, the identified common host-dependencies may present new targets for exploration by host-directed antiviral therapeutics.
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