gibco-cts-treg-dynabeads-xpander-quote-request-new-head-image

Gibco CTS Dynabeads Treg Xpander provides an optimized activation signal for activation and expansion of Regulatory T cells and yields high fold expansion of suppressive Tregs with a stable Treg phenotype, which is essential for use of Tregs in clinical applications.

Key features

  • Scalable technology for robust activation and expansion of Regulatory T cells
  • Clinically relevant numbers of Regulatory T cells with >800 fold expansion after two stimulations
  • Aseptically manufactured and ready for clinical trials and commercial manufacturing
  • Maintained Treg phenotype (FoxP3) and suppressive function
  • Drug Master file available
  • Conformity with cGMP guidelines

High Fold Expansion

High-Fold-Expansion

Figure 1. Optimized activation signal expands Tregs to clinically relevant numbers.

Flow sorted regulatory T cells were expanded with CTS Dynabeads Treg Xpander, CTS DynabeadsCD3/CD28 or competitor technology for 14 days with restimulation at day 9.

High suppressive potential

High-suppressive-potential

Figure 2. Optimized activation signal expands Tregs with high suppressive potential.

Magnetically isolated regulatory T Cells were expanded three times with CTS DynabeadsTregXpander for 14 days. Expanded Tregs are highly suppressive.

* Required field

*
*
*
 
 
*
*
*
 
 
 
 
*
*
*