The screening and routine quantitation of pesticide residues in food products is one of the most important and demanding applications in food safety. Despite the recent technological advancements in LC-MS, it is still challenging to quantify hundreds of LC-amenable pesticide residues with a robust, sensitive workflow solution. This presentation describes the development and implementation of compete workflow solutions based on LC-MS/MS and LC-HRAM -MS/MS. These ready-to-go solutions have been validated in three matrices across four different laboratories. In addition, customized software used for data acquisition and processing allows the users to rapidly implement these methods and enhance productivity.