Hyphenation of charge variant analysis using pH gradient cation exchange chromatography with high resolution Thermo Scientific Orbitrap mass spectrometry under native conditions (CVA-MS) has recently been described. This webcast will demonstrate the power of CVA-MS for profiling microheterogeneity of biopharmaceutical product quality attributes on both drug substance and drug product. In addition, the webcast will demonstrate how high-resolution native LC-MS can be applied for automated process monitoring when combined with automation solutions to create a data generation engine to support Manufacturing 4.0.

About the presenter

Jonathan Bones, Principal Investigator, National Institute for Bioprocessing Research and Training

Jonathan Bones, Principal Investigator, National Institute for Bioprocessing Research and Training

Jonathan received his PhD in Analytical Chemistry from Dublin City University in 2007. He then moved to The National Institute for Bioprocessing Research and Training, working within the GlycoScience Laboratory. In 2010, Jonathan was appointed the John Hatsopoulos Research Scholar at Northeastern University, Boston. He returned to NIBRT in 2012 and is the Principal Investigator of the NIBRT Characterization and Comparability Laboratory and an Associate Professor in the School of Chemical and Bioprocess Engineering at University College Dublin.

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