The results of the studies within this technical note indicate that the ISQ 7000 GC-MS system, configured with the AEI or with the Extractabrite ion sources, delivers in both cases very high quality mass spectra. In both configurations, the ISQ 7000 GC-MS can be confidently used for identification of untargeted compounds in screening experiments using the available commercial mass spectral libraries. The added advantage of the AEI source to increase ionization efficiency and extend the robustness towards difficult matrices, offers the possibility to expand the analytical capability of the laboratory. The ISQ 7000 GC-MS system configured with AEI source is therefore a valuable solution any time ultra sensitivity and robustness is required to respond to challenging analytical needs.