Unraveling Complex Biotherapeutics: Native Tandem Mass Spectrometry on Heterogeneous Glycoproteins and Protein Complexes

As the molecular complexity of biotherapeutics progresses beyond monoclonal antibodies, the need for innovative approaches to facilitate protein characterization becomes increasingly valuable. This webcast discusses the analytical challenges heterogeneous glycoproteins can present, and offers native tandem mass spectral strategies for comprehensive characterization, including workflows enabled through unique features of the new Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer.

About the presenter

Wendy Sandoval, Principal Scientific Manager in Research, Genentech

Wendy is the leader of the Translational Mass Spectrometry group in the Proteomics Department in Research at Genentech. Her group focuses on both bottom up and top down mass spectrometry-based strategies to help elucidate protein structure and function. During her more than twenty years at Genentech, Wendy has co-authored over 60 papers, edited two books and been involved in multiple patent applications.