A new data-dependent acquisition workflow is developed by using real-time background subtraction on a Thermo Scientific Orbitrap ID-X Tribrid mass spectrometer with AcquireX intelligent data acquisition strategy. This workflow enables collecting a complete dataset of high-resolution full MS and MSn scans of all potential metabolites in automated fashion, which needs neither pre-existing knowledge nor building exclusion and inclusion lists manually. Customized data-mining software is used for in-depth metabolite identification and structural elucidation. The results demonstrate that the Orbitrap ID-X MS with AcquireX data acquisition strategy coupled with advanced data processing software can improve metabolite analysis efficiency and quality.

About the presenter

Qian Ruan, Senior Research Investigator, Bristol Myers-Squibb

Qian Ruan, Senior Research Investigator, Bristol Myers-Squibb

Dr. Qian Ruan is a senior investigator at the Department of Metabolism and Pharmacokinetics of Bristol-Myers Squibb. Dr. Ruan obtained his bachelor’s degree in Chemistry in Peking University, China and Ph.D. in biochemistry in New York University. Later, he joined the DMPK group of BMS and has been working in BMS for 14 years. His research interest focuses on drug metabolism and application sciences. He has co-authored 17 peer reviewed papers and given many oral presentations in international conferences.

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