The data obtained from the experiments performed demonstrate that the ISQ 7000 GC-MS system with AEI source, in combination with the HyperSep Verify CX cartridge for sample preparation and Chromeleon CDS for data processing, provided a single quick, cost effective, and robust method for the general unknown screening. This method can be used for routine analysis of drugs of abuse in urine with a sample throughput of >12,000 samples/year.
The concentration factor of 60 gained through sample preparation and the enhanced sensitivity of the ion source made it possible to reach low detection limits, which are much more sensitive than the results gained in immunological testing. This is a big advantage, especially for new psychoactive substances.
Chromatographic deconvolution is an absolutely invaluable tool for this kind of analysis, where hundreds of substances are present in the chromatograms. Manual data interrogation would be time consuming and would require a highly experienced analyst.
The ISQ 7000 GC-MS system in combination with Chromeleon CDS software and AnalyzerPro software provides the perfect workflow for the general unknown screening for drugs of abuse.