Chlordiazepoxide/clidinium bromide is a drug consisting of fixed ratio of chlordiazepoxide and clidinium bromide and used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.
There is a requirement of selective and sensitive quantitative analysis of the peak plasma concentration with linear dynamics of LC-MS/MS instrument to support both nanogram and picogram levels together in the same run and with capability to produce reproducible and reliable concentration data for pharmacokinetic analysis and support in development of better formulations in future.
This poster describes the advantage of using the highly sensitive, selective, and robust Thermo Scientific™ TSQ Altis™ Triple Quadrupole Mass Spectrometer in achieving the accurate and precise concentrations of Chlordiazepoxide and Clidinium in human plasma.
