Actinomycin D is an antineoplastic antibiotic which inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. Actinomycin D is a widely used intercalating transcription inhibitor. This compound acts by binding to DNA at dG residues.
Keep your irreplaceable cultures contamination freeResearchers are typically concerned about two types of cell culture contamination: the contamination of cell cultures with microbiological organisms and the contamination of one cell line with another. Both types of contamination are extremely prevalent, and the possibility of contamination—and the impact on results—cannot be underestimated. The decision to use antibiotics and antimycotics to prevent contamination should be based on the individual researcher’s needs and experience.
We manufacture a wide array of antibiotics and antimycotics to control contamination arising from bacteria, fungi, mycoplasma, and yeast. While researchers may attempt to eliminate or control contaminations with antibiotics or antimycotics, it should be noted that these substances can be toxic to certain cell lines. Before using, it is essential to first perform a dose-response test to determine the level at which toxicity begins.