This gene encodes a multifunctional protein that localizes both in the cytoplasm and in the nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage and plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants.
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AIMP3; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS-interacting multifunctional protein 3; Elongation factor p18; Eukaryotic translation elongation factor 1 epsilon-1; Multisynthase complex auxiliary component p18; multisynthetase complex auxiliary component p18; p18 component of aminoacyl-tRNA synthetase; p18 component of aminoacyl-tRNA synthetase complex