Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; B7H2; B7RP1; GL50; ICOS Ligand; ICOS-L; ICOSL; inducible T-cell co-stimulator ligand; KIAA0653; transmembrane protein B7-H2 ICOS ligand
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